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Antimicrobial Agents and Chemotherapy, June 2008, p. 2223-2225, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01410-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Daptomycin Exerts Bactericidal Activity without Lysis of Staphylococcus aureus{triangledown}

Nicole Cotroneo,1 Robert Harris,2 Nancy Perlmutter,3 Terry Beveridge,2,4,{dagger} and Jared A. Silverman1*

Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, Lexington, Massachusetts 02421,1 University of Guelph, Guelph, Ontario, Canada N1G 2W1,2 Howard M. Shapiro, M.D., P.C., West Newton, Massachusetts,3 MicroTEM, Inc., Elora, Ontario, Canada N0B 1S04

Received 31 October 2007/ Returned for modification 28 December 2007/ Accepted 24 March 2008

The ability of daptomycin to produce bactericidal activity against Staphylococcus aureus while causing negligible cell lysis has been demonstrated using electron microscopy and the membrane integrity probes calcein and ToPro3. The formation of aberrant septa on the cell wall, suggestive of impairment of the cell division machinery, was also observed.

* Corresponding author. Mailing address: Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, Lexington, MA 02421. Phone: (781) 860-8405. Fax: (781) 861-1154. E-mail: Jared.Silverman{at}Cubist.com

{triangledown} Published ahead of print on 31 March 2008.

{dagger} Deceased.

Antimicrobial Agents and Chemotherapy, June 2008, p. 2223-2225, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01410-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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  • Sarig, H., Rotem, S., Ziserman, L., Danino, D., Mor, A. (2008). Impact of Self-Assembly Properties on Antibacterial Activity of Short Acyl-Lysine Oligomers. Antimicrob. Agents Chemother. 52: 4308-4314 [Abstract] [Full Text]  
  • Hobbs, J. K., Miller, K., O'Neill, A. J., Chopra, I. (2008). Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus. J Antimicrob Chemother 62: 1003-1008 [Abstract] [Full Text]  
  • Hawkey, P. M. (2008). Pre-clinical experience with daptomycin. J Antimicrob Chemother 62: iii7-iii14 [Abstract] [Full Text]  


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