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Antimicrobial Agents and Chemotherapy, June 2008, p. 2232-2235, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01245-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Radiofungicidal Effects of External Gamma Radiation and Antibody-Targeted Beta and Alpha Radiation on Cryptococcus neoformans{triangledown}

Ruth A. Bryan,1 Xianchun Huang,1 Alfred Morgenstern,2 Frank Bruchertseifer,2 Arturo Casadevall,3,4 and Ekaterina Dadachova1,3*

Department of Nuclear Medicine,1 European Commission, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany,2 Department of Microbiology and Immunology,3 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York4

Received 23 September 2007/ Returned for modification 13 January 2008/ Accepted 22 March 2008

We evaluated the clonogenic survival, membrane permeability, metabolic activity (XTT reduction), and apoptosis (FLICA binding) of Cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody. We found that gamma, beta, and alpha radiation affected cells through different pathways.

* Corresponding author. Mailing address: Albert Einstein College of Medicine, Department of Nuclear Medicine, 1695A Eastchester Rd., Bronx, NY 10461. Phone: (718) 405-8485. Fax: (718) 405-8457. E-mail: edadacho{at}aecom.yu.edu

{triangledown} Published ahead of print on 31 March 2008.

Antimicrobial Agents and Chemotherapy, June 2008, p. 2232-2235, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01245-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Bryan, R. A., Jiang, Z., Huang, X., Morgenstern, A., Bruchertseifer, F., Sellers, R., Casadevall, A., Dadachova, E. (2009). Radioimmunotherapy Is Effective against High-Inoculum Cryptococcus neoformans Infection in Mice and Does Not Select for Radiation-Resistant Cryptococcal Cells. Antimicrob. Agents Chemother. 53: 1679-1682 [Abstract] [Full Text]  


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