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Antimicrobial Agents and Chemotherapy, June 2008, p. 2244-2246, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.00231-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

First Report of cfr-Mediated Resistance to Linezolid in Human Staphylococcal Clinical Isolates Recovered in the United States {triangledown}

Rodrigo E. Mendes,1 Lalitagauri M. Deshpande,1 Mariana Castanheira,1 Joseph DiPersio,2 Michael A. Saubolle,3 and Ronald N. Jones1*

JMI Laboratories, North Liberty, Iowa,1 Summa Health System, Akron, Ohio,2 Laboratory Sciences of Arizona, Banner Health, Phoenix, Arizona3

Received 19 February 2008/ Returned for modification 5 March 2008/ Accepted 30 March 2008

Linezolid resistance has dominantly been mediated by mutations in 23S rRNA or ribosomal protein L4 genes. Recently, cfr has demonstrated the ability to produce a phenotype of resistance to not only oxazolidinones, but also other antimicrobial classes (phenicols, lincosamides, pleuromutilins, and streptogramin A). We describe the first detection of cfr-mediated linezolid resistance in Staphylococcus aureus and Staphylococcus epidermidis recovered from human infection cases monitored during the 2007 LEADER Program.

* Corresponding author. Mailing address: JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 655-3371. E-mail: ronald-jones{at}jmilabs.com

{triangledown} Published ahead of print on 7 April 2008.

Antimicrobial Agents and Chemotherapy, June 2008, p. 2244-2246, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.00231-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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