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Antimicrobial Agents and Chemotherapy, June 2008, p. 2247-2249, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.00109-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Bovicin HC5, a Lantibiotic Produced by Streptococcus bovis HC5, Catalyzes the Efflux of Intracellular Potassium but Not ATP {triangledown}

Hilário C. Mantovani1,{dagger} and James B. Russell2*

Department of Microbiology, Cornell University,1 Agricultural Research Service, USDA, Ithaca, New York 148532

Received 25 January 2008/ Returned for modification 27 February 2008/ Accepted 8 March 2008

Bovicin HC5, a broad-spectrum lantibiotic produced by Streptococcus bovis HC5, catalyzed the efflux of intracellular potassium from Streptococcus bovis JB1, a sensitive strain. The level of ATP also decreased, but this decline appeared to be caused by the activity of the F1F0 ATPase rather than efflux per se.

* Corresponding author. Mailing address: ARS/USDA, Plant Soil and Nutrition Laboratory, Tower Road, Ithaca, NY 14853. Phone: (607) 255-4508. Fax: (607) 255-2739. E-mail: James.Russell{at}ars.usda.gov

{triangledown} Published ahead of print on 17 March 2008.

{dagger} Present address: Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.

Antimicrobial Agents and Chemotherapy, June 2008, p. 2247-2249, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.00109-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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