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Antimicrobial Agents and Chemotherapy, June 2008, p. 2256-2259, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.00070-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Increasing Incidence of Linezolid-Intermediate or -Resistant, Vancomycin-Resistant Enterococcus faecium Strains Parallels Increasing Linezolid Consumption{triangledown}

Marc H. Scheetz,1,2* Stephanie A. Knechtel,2 Michael Malczynski,3 Michael J. Postelnick,2 and Chao Qi3

Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, Chicago, Illinois,1 Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois,2 Department of Pathology, Clinical Microbiology Division, Northwestern Memorial Hospital, Chicago, Illinois3

Received 17 January 2008/ Returned for modification 5 March 2008/ Accepted 29 March 2008

Clinical enterococcal resistance to linezolid is defined by the presence of the G2576T mutation. We evaluated the incidence of genetically proven linezolid resistance among vancomycin-resistant Enterococcus faecium strains and linezolid consumption for a possible association. A relationship was found (r2 = 0.73, P = 0.03) and predicts increasing resistance with current trends of linezolid use.

* Corresponding author. Mailing address: Midwestern University Chicago College of Pharmacy, Infectious Diseases Pharmacist, Northwestern Memorial Hospital, 251 E. Huron St., Feinberg Pavilion LC-700, Chicago, IL 60611. Phone: (630) 515-6116. Fax: (630) 515-6958. E-mail: mscheetz{at}nmh.org

{triangledown} Published ahead of print on 7 April 2008.

Antimicrobial Agents and Chemotherapy, June 2008, p. 2256-2259, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.00070-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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