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Antimicrobial Agents and Chemotherapy, June 2008, p. 2263-2265, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01568-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment{triangledown}

John D. Cleary,1* Guillermo Garcia-Effron,2 Stanley W. Chapman,1 and David S. Perlin2

Mycotic Research Center, University of Mississippi Schools of Pharmacy and Medicine, Jackson, Mississippi,1 Public Health Research Institute, UMDNJ-New Jersey Medical School, Newark, New Jersey2

Received 5 December 2007/ Returned for modification 20 January 2008/ Accepted 22 March 2008

We describe a case of recurring Candida glabrata infection in a 68-year-old African-American female on caspofungin therapy. The initial isolate was susceptible, but isolates recovered during following relapses were not. All isolates were clonal, and high-MIC strains contained a mutation in the highly conserved hot spot 1 region of Fks1p.

* Corresponding author. Mailing address: Departments of Pharmacy Practice & Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MI 39216. Phone: (601) 984-2617. Fax: (601) 984-2618. E-mail: Jcleary{at}medicine.umsmed.edu

{triangledown} Published ahead of print on 31 March 2008.

Antimicrobial Agents and Chemotherapy, June 2008, p. 2263-2265, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01568-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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