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Antimicrobial Agents and Chemotherapy, June 2008, p. 2279-2282, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01620-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Antistreptococcal Activity of AR-709 Compared to That of Other Agents{triangledown}

Kathy Smith,1 Lois M. Ednie,1 Peter C. Appelbaum,1* Stephen Hawser,2 and Sergio Lociuro2

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 Arpida AG, Reinach, Switzerland2

Received 18 December 2007/ Returned for modification 12 March 2008/ Accepted 15 March 2008

Against 300 strains of pneumococci and 100 group A streptococci of differing β-lactam, macrolide, and quinolone resistance phenotypes, AR-709 was very active, with all MICs being ≤2 µg/ml. Furthermore, AR-709 was active against strains that were both susceptible and resistant to trimethoprim-sulfamethoxazole.

* Corresponding author. Mailing address: Department of Pathology, H083 Room C6518, Hershey Medical Center, 500 University Dr., Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 24 March 2008.

Antimicrobial Agents and Chemotherapy, June 2008, p. 2279-2282, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.01620-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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