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Antimicrobial Agents and Chemotherapy, July 2008, p. 2653-2656, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.01329-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Synergy of Human Immunodeficiency Virus Protease Inhibitors with Chloroquine against Plasmodium falciparum In Vitro and Plasmodium chabaudi In Vivo{triangledown}

Zhengxiang He, Li Qin, Lili Chen, Nanzheng Peng, Jianlan You, and Xiaoping Chen*

Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510663, China

Received 16 October 2007/ Returned for modification 7 January 2008/ Accepted 21 April 2008

The synergy of the activities between chloroquine and various human immunodeficiency virus protease inhibitors was investigated in chloroquine-resistant and -sensitive malaria parasites. In both in vitro and in vivo assay systems, ritonavir was found to be the most potent in potentiating the antimalarial action of chloroquine.

* Corresponding author. Mailing address: Laboratory of Pathogen Biology, Guangzhou Institute of Biomedicine and Health, Guangzhou International Business Incubator, Guangzhou Science Park, Guangzhou, 510663, China. Phone: (86) 20-32290619. Fax: (86) 20-32290706. E-mail: chen_xiaoping{at}gibh.ac.cn

{triangledown} Published ahead of print on 28 April 2008.

Antimicrobial Agents and Chemotherapy, July 2008, p. 2653-2656, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.01329-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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