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Antimicrobial Agents and Chemotherapy, July 2008, p. 2657-2659, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.01459-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Gene Amplification of the Multidrug Resistance 1 Gene of Plasmodium vivax Isolates from Thailand, Laos, and Myanmar{triangledown}

Mallika Imwong,1* Sasithon Pukrittayakamee,1,2 Wirichada Pongtavornpinyo,1 Supatchara Nakeesathit,1 Shalini Nair,3 Paul Newton,4 Francois Nosten,1,5,6 Timothy J. C. Anderson,3 Arjen Dondorp,1,6 Nicholas P. J. Day,1,6 and Nicholas J. White1,6

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand,1 The Royal Institute, Grand Palace, Bangkok, Thailand,2 Southwest Foundation for Biomedical Research, San Antonio, Texas,3 Mahosot Hospital Wellcome Trust-Mahosot-Oxford Tropical Medicine Research Collaboration Vientiane, Laos PDR,4 Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand,5 Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom6

Received 11 November 2007/ Returned for modification 22 January 2008/ Accepted 10 April 2008

Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.

* Corresponding author. Mailing address: Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. Phone: (66) 2 354 9172. Fax: (66) 2 354 9169. E-mail: noi{at}tropmedres.ac

{triangledown} Published ahead of print on 28 April 2008.

Antimicrobial Agents and Chemotherapy, July 2008, p. 2657-2659, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.01459-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Orjuela-Sanchez, P., de Santana Filho, F. S., Machado-Lima, A., Chehuan, Y. F., Costa, M. R. F., Alecrim, M. d. G. C., del Portillo, H. A. (2009). Analysis of Single-Nucleotide Polymorphisms in the crt-o and mdr1 Genes of Plasmodium vivax among Chloroquine-Resistant Isolates from the Brazilian Amazon Region. Antimicrob. Agents Chemother. 53: 3561-3564 [Abstract] [Full Text]  
  • Baird, J. K. (2009). Resistance to Therapies for Infection by Plasmodium vivax. Clin. Microbiol. Rev. 22: 508-534 [Abstract] [Full Text]  


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