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Antimicrobial Agents and Chemotherapy, July 2008, p. 2660-2662, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.00785-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Susceptibility of Chlamydia trachomatis to the Excipient Hydroxyethyl Cellulose: pH and Concentration Dependence of Antimicrobial Activity{triangledown}

Ali A. Abdul Sater, David M. Ojcius, and Matthew P. Meyer*

School of Natural Sciences, University of California, Merced, California 95344

Received 18 June 2007/ Returned for modification 26 November 2007/ Accepted 7 April 2008

Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.

* Corresponding author. Mailing address: School of Natural Sciences, University of California, P.O. Box 2039, Merced, CA 95344. Phone: (209) 228-2982. Fax: (209) 228-4053. E-mail: mmeyer{at}ucmerced.edu

{triangledown} Published ahead of print on 14 April 2008.

Antimicrobial Agents and Chemotherapy, July 2008, p. 2660-2662, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.00785-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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