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Antimicrobial Agents and Chemotherapy, July 2008, p. 2680-2682, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.00158-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Presence of Plasmid-Mediated Quinolone Resistance in Klebsiella pneumoniae Isolates Possessing blaKPC in the United States{triangledown}

Andrea Endimiani,1* Lenore L. Carias,1 Andrea M. Hujer,1 Christopher R. Bethel,1 Kristine M. Hujer,1 Federico Perez,2 Rebecca A. Hutton,1 William R. Fox,3 Geraldine S. Hall,3 Michael R. Jacobs,4 David L. Paterson,5 Louis B. Rice,1 Stephen G. Jenkins,6 Fred C. Tenover,7 and Robert A. Bonomo1,8*

Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106,1 Division of Infectious Diseases and HIV Medicine, University Hospital Case Medical Center, Cleveland, Ohio 44106,2 Cleveland Clinic Foundation, Cleveland, Ohio 44195,3 Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106,4 University of Pittsburgh Medical Center, Pittsburgh, PA 15212,5 Mount Sinai Medical Center, New York, New York 10029,6 Office of Antimicrobial Resistance, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,7 Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 441068

Received 4 February 2008/ Returned for modification 16 March 2008/ Accepted 12 April 2008

The presence of plasmid-mediated quinolone resistance genes [i.e., qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA] was evaluated among 42 blaKPC-containing Klebsiella pneumoniae isolates collected in the eastern United States. One isolate carried the blaKPC-3 and qnrB19 genes on the same conjugative plasmid, whereas another carried the blaKPC-3 and qnrA1 genes on separate plasmids.

* Corresponding author. Mailing address: Infectious Diseases Section, Department of Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800, ext. 4399. Fax: (216) 231-3482. E-mail for Robert A. Bonomo: robert.bonomo{at}med.va.gov. E-mail for Andrea Endimiani: aendimiani{at}tin.it

{triangledown} Published ahead of print on 21 April 2008.

Antimicrobial Agents and Chemotherapy, July 2008, p. 2680-2682, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.00158-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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