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Antimicrobial Agents and Chemotherapy, July 2008, p. 2691-2692, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.00217-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Accumulation of 99mTc-Ciprofloxacin in Staphylococcus aureus and Pseudomonas aeruginosa{triangledown}

J. M. Sierra,1* D. Rodriguez-Puig,2 A. Soriano,1 J. Mensa,1 C. Piera,2 and J. Vila3

Department of Infectious Diseases, CDB,1 Department of Nuclear Medicine,2 Department of Microbiology, Hospital Clinic, IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain3

Received 15 February 2008/ Returned for modification 17 March 2008/ Accepted 5 May 2008

The use of radiopharmaceuticals for the diagnosis of infection is increasing due to their ability to distinguish between septic and aseptic inflammation. The aim of this study was to analyze the intracellular accumulation of technetium-99m-ciprofloxacin in strains of Staphylococcus aureus and Pseudomonas aeruginosa harboring an overexpression of NorA and MexAB-OprM, respectively.

* Corresponding author. Mailing address: Dept. of Infectious Diseases, Hospital Clinic of Barcelona, Villarroel 170, Esc 11-5 planta, 08036 Barcelona, Spain. Phone: 34 93 2275708. Fax: 34 93 4514438. E-mail: jmsierra{at}clinic.ub.es

{triangledown} Published ahead of print on 12 May 2008.

Antimicrobial Agents and Chemotherapy, July 2008, p. 2691-2692, Vol. 52, No. 7
0066-4804/08/$08.00+0     doi:10.1128/AAC.00217-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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