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Antimicrobial Agents and Chemotherapy, August 2008, p. 2929-2932, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00349-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

ISEcp1-Mediated Transposition of qnrB-Like Gene in Escherichia coli{triangledown}

Vincent Cattoir,1 Patrice Nordmann,1* Jesus Silva-Sanchez,2 Paula Espinal,3 and Laurent Poirel1

Service de Bactériologie-Virologie, INSERM U914 "Emerging Resistance to Antibiotics," Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre, France,1 Departamento de Resistencia Bacteriana, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico,2 Facultad de Ciencias de la Salud, Universidad del Sinú, Montería, Colombia3

Received 12 March 2008/ Returned for modification 27 April 2008/ Accepted 24 May 2008

A novel QnrB-like plasmid-mediated resistance determinant, QnrB19, was identified from an Escherichia coli clinical isolate from Colombia. Its gene was associated with an ISEcp1-like insertion element that did not act as a promoter for its expression. Using an in vitro model of transposition, we showed that the ISEcp1-like element was able to mobilize the qnrB19 gene.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie-Hygiène, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.aphp.fr

{triangledown} Published ahead of print on 2 June 2008.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2929-2932, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00349-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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