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Antimicrobial Agents and Chemotherapy, August 2008, p. 2937-2939, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00036-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Ofloxacin-Resistant Mycobacterium tuberculosis Strains from Russia{triangledown} ,{dagger}

Igor Mokrousov,1,2* Tatiana Otten,3 Olga Manicheva,3 Yulia Potapova,3 Boris Vishnevsky,3 Olga Narvskaya,1 and Nalin Rastogi2*

Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russia,1 Unité de la Tuberculose et des Mycobactéries, Institut Pasteur de Guadeloupe, Abymes 97183, Guadeloupe, France,2 Laboratory of Microbiology of Tuberculosis, The Research Institute of Phthisiopulmonology, 193036 St. Petersburg, Russia3

Received 9 January 2008/ Returned for modification 27 February 2008/ Accepted 5 June 2008

In this work, we studied the variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in northwest Russia. Comparison with spoligotyping data suggested that similar to the spread of multidrug-resistant tuberculosis, the spread of fluoroquinolone-resistant tuberculosis in Russia may be due, at least partly, to the prevalence of the Beijing genotype in a local population of M. tuberculosis.

* Corresponding author. Mailing address for Igor Mokrousov: Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, 197101 St. Petersburg, Russia. Phone: 7812 2332149. Fax: 7812 232 92 17. E-mail: igormokrousov{at}yahoo.com. Mailing address for Nalin Rastogi: Unité de la Tuberculose et des Mycobactéries, Institut Pasteur de Guadeloupe, Abymes 97183, Guadeloupe, France. Phone: 590-590-893881. Fax: 590-590-893880. E-mail: nrastogi{at}pasteur-guadeloupe.fr

{triangledown} Published ahead of print on 16 June 2008.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2937-2939, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00036-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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