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Antimicrobial Agents and Chemotherapy, August 2008, p. 2940-2942, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01581-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Tigecycline against Multidrug-Resistant Acinetobacter baumannii and Selection of Tigecycline-Amikacin Synergy{triangledown}

Ellen S. Moland,1 David W. Craft,2,{dagger} Seong-geun Hong,1 Soo-young Kim,1 Lucas Hachmeister,1 Shimon D. Sayed,1 and Kenneth S. Thomson1*

Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178,1 Walter Reed Army Medical Center, Washington, DC2

Received 7 December 2007/ Returned for modification 9 March 2008/ Accepted 26 May 2008

Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178-0213. Phone: (402) 280-2921. Fax: (402) 280-1875. E-mail: kstaac{at}creighton.edu

{triangledown} Published ahead of print on 2 June 2008.

{dagger} Present address: Ninth Area Medical Laboratory, 5158 Blackhawk Drive, Aberdeen Proving Grounds (Edgewood Area), MD 21010.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2940-2942, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01581-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lee, J., Patel, G., Huprikar, S., Calfee, D. P., Jenkins, S. G. (2009). Decreased Susceptibility to Polymyxin B during Treatment for Carbapenem-Resistant Klebsiella pneumoniae Infection. J. Clin. Microbiol. 47: 1611-1612 [Full Text]  
  • Gordon, N. C., Wareham, D. W. (2009). A review of clinical and microbiological outcomes following treatment of infections involving multidrug-resistant Acinetobacter baumannii with tigecycline. J Antimicrob Chemother 63: 775-780 [Abstract] [Full Text]  


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