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Antimicrobial Agents and Chemotherapy, August 2008, p. 2950-2954, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01672-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Spread of OXA-48-Positive Carbapenem-Resistant Klebsiella pneumoniae Isolates in Istanbul, Turkey{triangledown}

Amélie Carrër,1 Laurent Poirel,1 Haluk Eraksoy,2 A. Atahan Cagatay,2 Selim Badur,3 and Patrice Nordmann1*

Service de Bactériologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre, France,1 Department of Infectious Diseases and Clinical Microbiology,2 Department of Microbiology, Istanbul Faculty of Medicine, Capa, Istanbul, Turkey3

Received 27 December 2007/ Returned for modification 10 February 2008/ Accepted 24 May 2008

The first outbreak of carbapenem-resistant Klebsiella pneumoniae isolates producing the plasmid-encoded carbapenem-hydrolyzing oxacillinase OXA-48 is reported. The 39 isolates belonged to two different clones and were collected at the University Hospital of Istanbul, Turkey, from May 2006 to February 2007, and they coproduced various β-lactamases (SHV-12, OXA-9, and TEM-1 for clone A and CTX-M-15, TEM-1, and OXA-1 for clone B).

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.aphp.fr

{triangledown} Published ahead of print on 2 June 2008.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2950-2954, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01672-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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