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Antimicrobial Agents and Chemotherapy, August 2008, p. 2959-2961, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00646-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evaluation of Etest Method for Determining Isavuconazole MICs against Cryptococcus gattii and Cryptococcus neoformans{triangledown}

George R. Thompson III,1* Annette W. Fothergill,2 Nathan P. Wiederhold,1,4,5 Ana C. Vallor,1 Brian L. Wickes,3 and Thomas F. Patterson1

Department of Internal Medicine, Division of Infectious Diseases,1 Fungus Testing Laboratory, Department of Pathology,2 Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas,3 University of Texas at Austin College of Pharmacy, Austin, Texas,4 University of Texas Health Science Center at San Antonio, Pharmacotherapy Education and Research Center, San Antonio, Texas5

Received 16 May 2008/ Returned for modification 17 May 2008/ Accepted 7 June 2008

We compared Etest with broth microdilution testing for isavuconazole activity against 92 Cryptococcus isolates. A 97.8% agreement was found between these methods, without major discrepancies (>2-well dilution difference). Our findings support the use of the Etest methodology as a reliable method for the determination of MICs against Cryptococcus spp.

* Corresponding author. Mailing address: Department of Internal Medicine, Division of Infectious Diseases, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229. Phone: (210) 567-6680. Fax: (210) 567-3303. E-mail: thompsong2{at}uthscsa.edu

{triangledown} Published ahead of print on 16 June 2008.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2959-2961, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00646-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Warn, P. A., Sharp, A., Parmar, A., Majithiya, J., Denning, D. W., Hope, W. W. (2009). Pharmacokinetics and Pharmacodynamics of a Novel Triazole, Isavuconazole: Mathematical Modeling, Importance of Tissue Concentrations, and Impact of Immune Status on Antifungal Effect. Antimicrob. Agents Chemother. 53: 3453-3461 [Abstract] [Full Text]  


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