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Antimicrobial Agents and Chemotherapy, August 2008, p. 2962-2965, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01341-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Plasmid-Mediated qnrB2 and Carbapenemase Gene blaKPC-2 Carried on the Same Plasmid in Carbapenem-Resistant Ciprofloxacin-Susceptible Enterobacter cloacae Isolates{triangledown}

Inna Chmelnitsky,1 Shiri Navon-Venezia,1 Jacob Strahilevitz,2 and Yehuda Carmeli1*

Division of Epidemiology, Tel-Aviv Medical Center, Tel Aviv, Israel,1 Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University, Jerusalem2

Received 18 October 2007/ Returned for modification 3 January 2008/ Accepted 28 May 2008

Fourteen out of 16 carbapenem-resistant quinolone-susceptible Enterobacter cloacae isolates were found to carry qnrB2 and blaKPC-2 genes encoded on the same plasmid. One isolate also carried the aac(6')-Ib-cr gene. Coexistence of quinolone resistance determinants and blaKPC-2 on the same plasmid in quinolone-susceptible E. cloacae isolates may have important clinical implications.

* Corresponding author. Mailing address: Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., Tel Aviv 64239, Israel. Phone: 972 3 692 5644. Fax: 972 3 697 4966. E-mail: yehudac{at}tasmc.health.gov.il

{triangledown} Published ahead of print on 2 June 2008.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2962-2965, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01341-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Strahilevitz, J., Jacoby, G. A., Hooper, D. C., Robicsek, A. (2009). Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat. Clin. Microbiol. Rev. 22: 664-689 [Abstract] [Full Text]  
  • Chmelnitsky, I., Hermesh, O., Navon-Venezia, S., Strahilevitz, J., Carmeli, Y. (2009). Detection of aac(6')-Ib-cr in KPC-producing Klebsiella pneumoniae isolates from Tel Aviv, Israel. J Antimicrob Chemother 64: 718-722 [Abstract] [Full Text]  
  • Govender, N., Smith, A. M., Karstaedt, A. S., Keddy, K. H., for the Group for Enteric, Respiratory and Meninge, (2009). Plasmid-mediated quinolone resistance in Salmonella from South Africa. J Med Microbiol 58: 1393-1394 [Full Text]  


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