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Antimicrobial Agents and Chemotherapy, August 2008, p. 2966-2969, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00165-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Antimalarial Trioxaquine DU1301 Alkylates Heme in Malaria-Infected Mice{triangledown}

Fatima Bousejra-El Garah,1 Catherine Claparols,1 Françoise Benoit-Vical,1,2 Bernard Meunier,3 and Anne Robert1*

Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4, France,1 Service de Parasitologie et Mycologie, CHU Rangueil, Université de Toulouse, TSA 50032, 31059 Toulouse Cedex 9, France,2 Palumed, rue Pierre et Marie Curie, BP 28262, 31682 Labège Cedex, France3

Received 5 February 2008/ Returned for modification 6 March 2008/ Accepted 3 June 2008

The in vivo alkylation of heme by the antimalarial trioxaquine DU1301 afforded covalent heme-drug adducts that were detected in the spleens of Plasmodium sp.-infected mice. This result indicates that the alkylation capacities of trioxaquines in mammals infected with Plasmodium strains are similar to that of artemisinin, a natural antimalarial trioxane-containing drug.

* Corresponding author. Mailing address: Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4, France. Phone: 33 5 61 33 31 26. Fax: 33 5 61 55 30 03. E-mail: anne.robert{at}lcc-toulouse.fr

{triangledown} Published ahead of print on 16 June 2008.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2966-2969, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00165-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cosledan, F., Fraisse, L., Pellet, A., Guillou, F., Mordmuller, B., Kremsner, P. G., Moreno, A., Mazier, D., Maffrand, J.-P., Meunier, B. (2008). Selection of a trioxaquine as an antimalarial drug candidate. Proc. Natl. Acad. Sci. USA 105: 17579-17584 [Abstract] [Full Text]  


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