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Antimicrobial Agents and Chemotherapy, August 2008, p. 2977-2979, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00175-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

VIM-15 and VIM-16, Two New VIM-2-Like Metallo-β-Lactamases in Pseudomonas aeruginosa Isolates from Bulgaria and Germany{triangledown}

Ines Schneider,1 Emma Keuleyan,2 Rudolf Rasshofer,3 Rumyana Markovska,4 Anne Marie Queenan,5 and Adolf Bauernfeind1*

MICOER-Institute, Munich, Germany,1 Medical Institute, Ministry of the Interior, Sofia, Bulgaria,2 Medizinisches Versorgungszentrum Labor Dr. Tiller and Partner, Munich, Germany,3 Department of Microbiology, Medical University, Sofia, Bulgaria,4 Johnson & Johnson Pharmaceutical Research and Development, Raritan, New Jersey5

Received 7 February 2008/ Returned for modification 27 March 2008/ Accepted 28 May 2008

Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new VIM-2 variants. VIM-15 had one amino acid substitution (Tyr218Phe) which caused a significant increase in hydrolytic efficiency. The substitution Ser54Leu, characterizing VIM-16, showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome.

* Corresponding author. Mailing address: MICOER-Institute, Hesseloherstrasse 4, 80802 Munich, Germany. Phone and fax: 49-89-3889 8766. E-mail: bauernfeind{at}aol.com

{triangledown} Published ahead of print on 2 June 2008.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2977-2979, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00175-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Strateva, T., Yordanov, D. (2009). Pseudomonas aeruginosa - a phenomenon of bacterial resistance. J Med Microbiol 58: 1133-1148 [Abstract] [Full Text]  


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