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Antimicrobial Agents and Chemotherapy, August 2008, p. 2980-2983, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00151-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Alteration of GyrA Amino Acid Required for Ciprofloxacin Resistance in Klebsiella pneumoniae Isolates in China{triangledown}

Yingmei Fu,1,2,{dagger} Lishuang Guo,1,{dagger} Yan Xu,1 Wenli Zhang,1 Jiaao Gu,1 Jianfeng Xu,1 Xiaobei Chen,1 Yuehui Zhao,1 Jiayu Ma,1 Xinghan Liu,2 and Fengmin Zhang1,2*

Department of Medical Microbiology, Harbin Medical University, Pathogenic Biology Key Laboratory of Heilongjiang Province, 194 Xue Fu Road, Harbin 150086, China,1 Bio-Pharmaceutical Key Laboratory of Heilongjiang Province, 194 Xue Fu Road, Harbin 150086, China2

Received 3 February 2008/ Returned for modification 21 April 2008/ Accepted 21 May 2008

Resistance to ciprofloxacin was detected in 111 (48.1%) isolates of Klebsiella pneumoniae from China. GyrA alterations were identified in the ciprofloxacin-resistant and ciprofloxacin-susceptible isolates. The results, including previously published data, indicate that the single substitution Ser83->Ile and three types of double mutations at Ser83 and Asp87 were required for ciprofloxacin resistance (P < 0.05).

* Corresponding author. Mailing address: Department of Medical Microbiology, Harbin Medical University, 194 Xue Fu Road, Harbin 150086, China. Phone and fax: 86-451-8666-9576. E-mail: fengminzhang{at}yahoo.com.cn

{triangledown} Published ahead of print on 27 May 2008.

{dagger} Y.F. and L.G. contributed equally to this work.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2980-2983, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00151-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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