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Antimicrobial Agents and Chemotherapy, August 2008, p. 2988-2989, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01662-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evaluation of Antibiotic Therapy for Eradication of "Candidatus Helicobacter heilmannii"{triangledown}

Hidenori Matsui,1,2* Chihiro Aikawa,1 Yukie Sekiya,2 Shinichi Takahashi,3 Somay Yamagata Murayama,1,2 and Masahiko Nakamura4*

Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641 Japan,1 Center for Basic Research, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan,2 3rd Department of Internal Medicine, Kyorin University, Mitaka, Tokyo 181-8611, Japan,3 Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan4

Received 24 December 2007/ Returned for modification 4 February 2008/ Accepted 12 May 2008

Triple-agent therapy with lansoprazole (15 mg/kg)-clarithromycin (50 mg/kg)-amoxicillin (50 mg/kg) twice daily for 7 days fully cleared "Candidatus Helicobacter heilmannii" from infected mouse stomachs. Moreover, gastric mucosa-associated lymphoid tissue lymphoma-like lesions in the stomach nearly disappeared in the treated mice 4 months after the therapy.

* Corresponding author. Mailing address for Hidenori Matsui (correspondence and reprint requests): Laboratory of Immunoregulation, Department of Infection Control and Immunology, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Phone and fax: 81-3-5791-6267. E-mail: hmatsui{at}lisci.kitasato-u.ac.jp. Mailing address for Masahiko Nakamura: Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Phone and fax: 81-3-3446-9036. E-mail: nakamuram{at}pharm.kitasato-u.ac.jp

{triangledown} Published ahead of print on 19 May 2008.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2988-2989, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01662-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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