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Antimicrobial Agents and Chemotherapy, September 2008, p. 3398-3407, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00149-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Profiling of Ceftaroline against a Collection of Recent Bacterial Clinical Isolates from across the United States{triangledown}

Yigong Ge,1 Donald Biek,1* George H. Talbot,1,{dagger} and Daniel F. Sahm2

Cerexa, Inc., Alameda, California,1 Eurofins Medinet, Herndon, Virginia2

Received 2 February 2008/ Returned for modification 22 March 2008/ Accepted 4 July 2008

This study evaluated the in vitro activity of ceftaroline, a novel cephalosporin with broad-spectrum activity against gram-negative and -positive pathogens, against 4,151 recent clinical isolates collected in the United States. Ceftaroline was very potent against bacteria found in community- and hospital-acquired infections, including methicillin-resistant Staphylococcus aureus, multidrug-resistant Streptococcus pneumoniae, and common Enterobacteriaceae spp.

* Corresponding author. Mailing address: Cerexa, Inc., 1751 Harbor Bay Parkway, Alameda, California. Phone: (510) 747-3956. Fax: (510) 747-3940. E-mail: dbiek{at}cerexa.com

{triangledown} Published ahead of print on 14 July 2008.

{dagger} Present address: Talbot Advisors, LLC, Maplewood Avenue, Wayne, Pennsylvania.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3398-3407, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00149-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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