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Antimicrobial Agents and Chemotherapy, September 2008, p. 3414-3417, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.01450-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Cell-Penetrating Peptide TP10 Shows Broad-Spectrum Activity against both Plasmodium falciparum and Trypanosoma brucei brucei{triangledown}

Romanico B. G. Arrighi,1,{dagger} Charles Ebikeme,3 Yang Jiang,2 Lisa Ranford-Cartwright,3 Michael P. Barrett,3 Ülo Langel,2 and Ingrid Faye1*

Department of Genetics, Microbiology, and Toxicology,1 Department of Neurochemistry, Stockholm University, 106 91 Stockholm, Sweden,2 Institute of Biomedical and Life Sciences, Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom3

Received 8 November 2007/ Returned for modification 13 January 2008/ Accepted 25 May 2008

Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both blood and mosquito stages, and against blood-stage Trypanosoma brucei brucei.

* Corresponding author. Mailing address: Department of Genetics, Microbiology, and Toxicology, Stockholm University, 106 91 Stockholm, Sweden. Phone: (46) 8161272. Fax: (46) 86129552. E-mail: Ingrid.Faye{at}gmt.su.se

{triangledown} Published ahead of print on 2 June 2008.

{dagger} Present address: Swedish Institute for Infectious Disease Control, SE-171 82 Stockholm, Sweden.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3414-3417, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.01450-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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