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Antimicrobial Agents and Chemotherapy, September 2008, p. 3427-3429, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00493-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The KQ Element, a Complex Genetic Region Conferring Transferable Resistance to Carbapenems, Aminoglycosides, and Fluoroquinolones in Klebsiella pneumoniae{triangledown}

Louis B. Rice,1,2* Lenore L. Carias,1 Rebecca A. Hutton,2 Susan D. Rudin,1 Andrea Endimiani,1 and Robert A. Bonomo1,2

Medical and Research Services, Louis Stokes Cleveland VA Medical Center,1 Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio2

Received 15 April 2008/ Returned for modification 30 May 2008/ Accepted 14 June 2008

The blaKPC-3 and qnrB19 determinants of transferable Klebsiella pneumoniae plasmid pLRM24 reside within a complex region consisting of a Tn1331 backbone into which a Tn4401-like element and qnrB19 mobilized by an adjacent ISEcp1 insertion sequence have been inserted. This novel element represents a coalescence of genes conferring multidrug resistance in K. pneumoniae.

* Corresponding author. Mailing address: Medical Service 111(W), Louis Stokes Cleveland VA Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800, ext. 4800. Fax: (216) 231-3289. E-mail: louis.rice{at}va.gov

{triangledown} Published ahead of print on 23 June 2008.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3427-3429, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00493-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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