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Antimicrobial Agents and Chemotherapy, September 2008, p. 3441-3443, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00357-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Microbiological and Genotypic Analysis of Methicillin-Resistant Staphylococcus aureus Bacteremia{triangledown}

Carlo McCalla,1 Davida S. Smyth,2 D. Ashley Robinson,2 Judith Steenbergen,3 Steven A. Luperchio,3 Pamela A. Moise,3 Vance G. Fowler Jr.,4 and George Sakoulas1*

Department of Medicine, New York Medical College, Valhalla, New York,1 Department of Microbiology and Immunology, New York Medical College, Valhalla, New York,2 Cubist Pharmaceuticals, Lexington, Massachusetts,3 Division of Infectious Disease, Duke University Medical Center, Durham, North Carolina4

Received 14 March 2008/ Returned for modification 4 May 2008/ Accepted 1 July 2008

In a recent landmark trial of bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) isolates, vancomycin MICs were ≥1 µg/ml for only 16% of the isolates, and accessory gene regulator (agr) function as measured by delta-hemolysin activity was absent or reduced in only 28.1% of the isolates. This clinical study did not capture a population of MRSA isolates predictive of vancomycin treatment failure.

* Corresponding author. Mailing address: Division of Infectious Diseases, New York Medical College, Munger Pavilion, Room 245, Valhalla, NY 10595. Phone: (914) 493-8865. Fax: (914) 594-4673. E-mail: george_sakoulas{at}nymc.edu

{triangledown} Published ahead of print on 7 July 2008.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3441-3443, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00357-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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