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Antimicrobial Agents and Chemotherapy, September 2008, p. 3444-3446, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00629-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Clinical Isolates of Aspergillus Species Remain Fully Susceptible to Voriconazole in the Post-Voriconazole Era{triangledown}

Jesús Guinea,1,2* Sandra Recio,1 Teresa Peláez,1,2 Marta Torres-Narbona,1 and Emilio Bouza1,2

Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain,1 CIBER de Enfermedades Respiratorias (CIBER RES CD06/06/0058), Palma de Mallorca, Spain2

Received 14 May 2008/ Returned for modification 3 June 2008/ Accepted 28 June 2008

We studied the activity of voriconazole against 400 clinical strains of Aspergillus from the pre-voriconazole (1999 to 2002) and post-voriconazole (2003 to 2007) periods. Although the mean MICs of strains from the post-voriconazole period were slightly higher (0.39 versus 0.57 µg/ml; P < 0.001), all strains were susceptible to voriconazole and presented an MIC of ≤2 µg/ml.

* Corresponding author. Mailing address: Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, C/Dr. Esquerdo 46, 28007 Madrid (Spain). Phone: 34915867163. Fax: 34915044906. E-mail: jguineaortega{at}yahoo.es

{triangledown} Published ahead of print on 7 July 2008.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3444-3446, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00629-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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