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Antimicrobial Agents and Chemotherapy, September 2008, p. 3454-3456, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00396-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats {triangledown}

Fumie Abe,1 Jun Ueyama,2 Noriyo Kawasumi,1 Masayuki Nadai,3 Tamon Hayashi,1 Miki Kato,1 Masafumi Ohnishi,1 Hiroko Saito,1 Naoshi Takeyama,4 and Takaaki Hasegawa1*

Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine, Nagakute-cho, Aichi-gun, Aichi 480-1195,1 Department of Medical Technology, Nagoya University School of Health Sciences, 1-1-20 Daikominami, Higashi-ku, Nagoya 461-8672,2 Faculty of Pharmaceutical Sciences, Meijo University, 150 Yagotoyama, Tenpaku-ku, Nagoya 468-8503,3 Department of Critical Care Medicine, Aichi Medical University School of Medicine, Nagakute-cho, Aichi-gun, Aichi 480-1195, Japan4

Received 24 March 2008/ Returned for modification 30 April 2008/ Accepted 23 June 2008

There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest that HDL and gamma globulin contribute to the pharmacokinetics of micafungin.

* Corresponding author. Mailing address: Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine, Nagakute-cho, Aichi-gun, Aichi 480-1195, Japan. Phone: 81-561-62-3311. Fax: 81-561-63-1028. E-mail: takahase{at}aichi-med-u.ac.jp

{triangledown} Published ahead of print on 30 June 2008.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3454-3456, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00396-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nicasio, A. M., Tessier, P. R., Nicolau, D. P., Knauft, R. F., Russomanno, J., Shore, E., Kuti, J. L. (2009). Bronchopulmonary Disposition of Micafungin in Healthy Adult Volunteers. Antimicrob. Agents Chemother. 53: 1218-1220 [Abstract] [Full Text]  


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