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Antimicrobial Agents and Chemotherapy, September 2008, p. 3457-3460, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00117-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Emergence and Acquisition of Fluoroquinolone-Resistant Gram-Negative Bacilli in the Intestinal Tracts of Mice Treated with Fluoroquinolone Antimicrobial Agents{triangledown}

Michael J. Pultz,1 Michelle M. Nerandzic,1 Usha Stiefel,1,2 and Curtis J. Donskey1,2*

Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio,1 Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio2

Received 26 January 2008/ Returned for modification 28 February 2008/ Accepted 25 June 2008

After mice received orogastric administration of a fluoroquinolone-resistant Klebsiella pneumoniae strain, subcutaneous treatment with ciprofloxacin, levofloxacin, and moxifloxacin promoted persistent low-density colonization in 10% to 40% of the mice, whereas treatment with clindamycin consistently promoted high-density colonization. No emergence of fluoroquinolone-resistant gram-negative bacilli was detected in the mice during or after treatment with the fluoroquinolone antimicrobial agents.

* Corresponding author. Mailing address: Infectious Diseases Section (111 W), Louis Stokes Cleveland VA Medical Center, 10701 East Blvd., Cleveland, Ohio 44106. Phone: (216) 791-3800, ext. 5103. Fax: (216) 229-8509. E-mail: curtisd123{at}yahoo.com

{triangledown} Published ahead of print on 7 July 2008.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3457-3460, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00117-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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