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Antimicrobial Agents and Chemotherapy, January 2009, p. 256-260, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00470-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antifungal Activities of Human Beta-Defensins HBD-1 to HBD-3 and Their C-Terminal Analogs Phd1 to Phd3{triangledown}

Viswanatha Krishnakumari, Nandini Rangaraj, and Ramakrishnan Nagaraj*

Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500 007, India

Received 9 April 2008/ Returned for modification 6 July 2008/ Accepted 14 September 2008

The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1, Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower-level activities than HBD-1 to HBD-3, although metabolic inhibitors did not render Phd1 to Phd3 inactive. Their activities were also less salt sensitive than those of HBD-1 to HBD-3. Confocal microscope images indicated that the initial site of action was the fungal membrane.

* Corresponding author. Mailing address: Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500 007, India. Phone: 91-40-27192589. Fax: 91-40-27160591. E-mail: nraj{at}ccmb.res.in

{triangledown} Published ahead of print on 22 September 2008.

Antimicrobial Agents and Chemotherapy, January 2009, p. 256-260, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00470-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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