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Antimicrobial Agents and Chemotherapy, January 2009, p. 287-291, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00746-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Nationwide Survey of CTX-M-Type Extended-Spectrum β-Lactamases among Klebsiella pneumoniae Isolates in Slovenian Hospitals {triangledown}

K. Mesko Meglic,1* S. Koren,1 M. F. I. Palepou,2 E. Karisik,2 D. M. Livermore,2 R. Pike,2 A. Andlovic,1 S. Jeverica,1 V. Krizan-Hergouth,1 M. Müller-Premru,1 K. Seme,1 the Slovenian ESBL Study Group {dagger} N. Woodford,2

Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Zaloska 4, 1105 Ljubljana, Slovenia,1 Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom2

Received 6 June 2008/ Returned for modification 20 August 2008/ Accepted 2 November 2008

Among 177 extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolates collected from 11 Slovenian hospitals in 2005 and 2006, 60 (34%), from eight hospitals, harbored genes for CTX-M enzymes, with blaCTX-M-15 detected by sequencing. These 60 isolates comprised 11 pulsed-field gel electrophoresis-defined strains, with several clusters of closely related isolates. Plasmids encoding CTX-M-15 enzyme were highly transmissible.

* Corresponding author. Mailing address: Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Zaloska 4, 1105 Ljubljana, Slovenia. Phone: 00386 1 543 74 46. Fax: 00386 1 543 74 01. E-mail: karmen.mesko{at}mf.uni-lj.si

{triangledown} Published ahead of print on 10 November 2008.

{dagger} The members of the Slovenian ESBL Study Group (in alphabetic order) are Jerneja Ambrozic Avgustin, Department of Biology, Biotechnical Faculty, University of Ljubljana; Ingrid Berce, Public Health Care Center Nova Gorica; Marina Bujko, Institute of Public Health of the Republic of Slovenia; Jerneja Fiser, General Hospital Dr. Franc Derganc; Tatjana Harlander, Public Health Care Center Novo Mesto; Martina Kavcic, Public Health Care Center Koper; Slavica Lorencic-Robnik, Public Health Care Center Maribor; Irena Piltaver, General Hospital Slovenj Gradec; Helena Ribic, Public Health Care Center Kranj; Iztok Strumbelj, Public Health Care Center Murska Sobota; Viktorija Tomic, University Clinic for Pulmonary and Allergic Diseases Golnik; and Tjasa Zohar-Cretnik, Public Health Care Center Celje.

Antimicrobial Agents and Chemotherapy, January 2009, p. 287-291, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00746-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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