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Antimicrobial Agents and Chemotherapy, January 2009, p. 298-302, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00657-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Klebsiella pneumoniae OmpA Confers Resistance to Antimicrobial Peptides{triangledown}

Enrique Llobet,1,2,{dagger} Catalina March,1,2,{dagger} Paloma Giménez,2 and José A. Bengoechea1,2,3,4*

Program Infection and Immunity, Fundación Caubet-CIMERA Illes Balears,1 Centro Investigación Biomédica en Red de Enfermedades Respiratorias (CibeRes), Bunyola,2 Área de Microbiología, Facultad Biología, Universitat Illes Balears, Palma Mallorca,3 Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain4

Received 19 May 2008/ Returned for modification 25 July 2008/ Accepted 5 November 2008

A Klebsiella pneumoniae ompA mutant was more susceptible to antimicrobial peptides (APs) than the wild type. Susceptibility did not result from surface changes other than the absence of OmpA. Our data suggest that OmpA is implicated in the activation of yet-unknown systems dedicated to ameliorating AP cytotoxicity.

* Corresponding author. Mailing address: Program Infection and Immunity, Fundació Caubet-CIMERA Illes Balears, Recinto Hospital Joan March, Carretera Sóller Km 12, 07110 Bunyola. Spain. Phone: 34 971 011780. Fax: 34 971 011797. E-mail: bengoechea{at}caubet-cimera.es

{triangledown} Published ahead of print on 17 November 2008.

{dagger} These authors contributed equally to this work.

Antimicrobial Agents and Chemotherapy, January 2009, p. 298-302, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00657-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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