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Antimicrobial Agents and Chemotherapy, January 2009, p. 306-308, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.01346-07
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Testing of Experimental Compounds in a Relapse Model of Tuberculosis Using Granulocyte-Macrophage Colony-Stimulating Factor Gene-Disrupted Mice{triangledown}

Lisa K. Woolhiser, Donald R. Hoff, Karen S. Marietta, Ian M. Orme, and Anne J. Lenaerts*

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523

Received 18 October 2007/ Returned for modification 8 April 2008/ Accepted 8 October 2008

This study describes an in vivo model for evaluating the sterilizing activity of compounds against persisting Mycobacterium tuberculosis. The initial treatment with isoniazid and rifampin in granulocyte-macrophage colony-stimulating factor gene-disrupted mice reduced the number of bacteria more than 99% within 3 weeks. A subsequent treatment with individual drugs was performed to assess their activity on the 1% of remaining bacilli and disease relapse.

* Corresponding author. Mailing address: Colorado State University, Department of Microbiology, Immunology and Pathology, 200 West Lake Street, Fort Collins, CO 80523. Phone: (970) 491-3079. Fax: (970) 491-1815. E-mail: Lenaerts{at}colostate.edu

{triangledown} Published ahead of print on 13 October 2008.

Antimicrobial Agents and Chemotherapy, January 2009, p. 306-308, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.01346-07
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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