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Antimicrobial Agents and Chemotherapy, January 2009, p. 312-315, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00988-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

A 6-Aminoquinolone Compound, WC5, with Potent and Selective Anti-Human Cytomegalovirus Activity{triangledown}

Beatrice Mercorelli,1 Giulia Muratore,1 Elisa Sinigalia,1 Oriana Tabarrini,2 Maria Angela Biasolo,1 Violetta Cecchetti,2 Giorgio Palù,1* and Arianna Loregian1*

Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, 35121 Padua, Italy,1 Department of Chemistry and Technology of Drugs, University of Perugia, 06123 Perugia, Italy2

Received 24 July 2008/ Returned for modification 6 September 2008/ Accepted 5 November 2008

We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of ~500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was ~10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.

* Corresponding author. Mailing address: Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, via Gabelli 63, 35121 Padua, Italy. Phone for A. Loregian: 39 049 8272363. Fax: 39 049 8272355. E-mail: arianna.loregian{at}unipd.it. Phone for G. Palù: 39 049 8272350. Fax: 39 049 8272355. E-mail: giorgio.palu{at}unipd.it

{triangledown} Published ahead of print on 17 November 2008.

Antimicrobial Agents and Chemotherapy, January 2009, p. 312-315, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00988-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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