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Antimicrobial Agents and Chemotherapy, January 2009, p. 316-318, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.01302-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Susceptibility of Mycobacterium bovis BCG Vaccine Strains to Antituberculous Antibiotics{triangledown}

Nicole Ritz,1,2,3 Marc Tebruegge,1,2,3 Tom G. Connell,1,2,3 Aina Sievers,4 Roy Robins-Browne,1,3,5 and Nigel Curtis1,2,3*

Department of Paediatrics, The University of Melbourne, Parkville, Australia,1 Infectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, Australia,2 Murdoch Children's Research Institute, Parkville, Australia,3 Victorian Infectious Diseases Reference Laboratories, North Melbourne, Australia,4 Department of Microbiology and Immunology, The University of Melbourne, Parkville, Australia5

Received 29 September 2008/ Returned for modification 8 October 2008/ Accepted 20 October 2008

Mycobacterium bovis BCG is one of the most commonly administered vaccines. Complications, including disseminated BCG disease, are rare but increasingly reported in immunodeficient children. There is growing recognition of the importance of differences between BCG vaccine strains. We determined the susceptibilities of five genetically distinct BCG vaccine strains to 12 antituberculous drugs.

* Corresponding author. Mailing address: Department of Paediatrics, The University of Melbourne, Royal Children's Hospital Melbourne, Flemington Road, Parkville, VIC 3052, Australia. Phone: 61 3 9345 4545. Fax: 61 3 9345 6667. E-mail: nigel.curtis{at}rch.org.au

{triangledown} Published ahead of print on 27 October 2008.

Antimicrobial Agents and Chemotherapy, January 2009, p. 316-318, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.01302-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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