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Antimicrobial Agents and Chemotherapy, January 2009, p. 319-322, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00595-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Tomopenem (CS-023/RO4908463) against Anaerobic Bacteria{triangledown}

Kaori Tanaka,1* Hiroshige Mikamo,2 Kenichi Nakao,1 Taku Ichiishi,1 Takatsugu Goto,1 Yuka Yamagishi,2 and Kunitomo Watanabe1

Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan,1 Department of Infection Control and Prevention, Aichi Medical University, 21 Karimata, Yazako, Nagakute-cho, Aichi-gun, Aichi 480-1195, Japan2

Received 7 May 2008/ Returned for modification 7 June 2008/ Accepted 17 October 2008

The antianaerobic activity of tomopenem, a new longer-half-life parenteral carbapenem, was compared with other carbapenems. Tomopenem showed broad activity against 63 reference species. The activity of tomopenem against 293 clinical isolates was potent (MIC90, 0.06 to 4 µg/ml) and comparable to those of meropenem and doripenem and more potent than that of panipenem.

* Corresponding author. Mailing address: Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan. Phone: 81-58-230-6555. Fax: 81-58-230-6551. E-mail: kktb{at}gifu-u.ac.jp

{triangledown} Published ahead of print on 27 October 2008.

Antimicrobial Agents and Chemotherapy, January 2009, p. 319-322, Vol. 53, No. 1
0066-4804/09/$08.00+0     doi:10.1128/AAC.00595-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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