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Antimicrobial Agents and Chemotherapy, October 2009, p. 4357-4367, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00077-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Aryl Rhodanines Specifically Inhibit Staphylococcal and Enterococcal Biofilm Formation{triangledown} ,{dagger}

Timothy J. Opperman,* Steven M. Kwasny, John D. Williams, Atiyya R. Khan, Norton P. Peet, Donald T. Moir, and Terry L. Bowlin

Microbiotix, Inc., Worcester, Massachusetts

Received 20 January 2009/ Returned for modification 10 March 2009/ Accepted 14 July 2009

Staphylococcus epidermidis and Staphylococcus aureus are the leading causative agents of indwelling medical device infections because of their ability to form biofilms on artificial surfaces. Here we describe the antibiofilm activity of a class of small molecules, the aryl rhodanines, which specifically inhibit biofilm formation of S. aureus, S. epidermidis, Enterococcus faecalis, E. faecium, and E. gallinarum but not the gram-negative species Pseudomonas aeruginosa or Escherichia coli. The aryl rhodanines do not exhibit antibacterial activity against any of the bacterial strains tested and are not cytotoxic against HeLa cells. Preliminary mechanism-of-action studies revealed that the aryl rhodanines specifically inhibit the early stages of biofilm development by preventing attachment of the bacteria to surfaces.

* Corresponding author. Mailing address: Microbiotix, Inc., One Innovation Dr., Worcester, MA 01605. Phone: (508) 757-2800. Fax: (508) 757-1999. E-mail: topperman{at}microbiotix.com

{triangledown} Published ahead of print on 3 August 2009.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, October 2009, p. 4357-4367, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00077-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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