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Antimicrobial Agents and Chemotherapy, October 2009, p. 4495-4497, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00237-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro 24-Hour Time-Kill Studies of Vancomycin and Linezolid in Combination versus Methicillin-Resistant Staphylococcus aureus{triangledown}

Shveta Rani Singh,1* Alfred E. Bacon III,2 David C. Young,3 and Kimberly A. Couch4

Department of Medicine—Pediatrics,1 Department of Internal Medicine,2 Department of Pathology, Section of Microbiology,3 Department of Pharmacy, Christiana Care Health System, 4755 Ogletown-Stanton Road, Newark, Delaware 197184

Received 19 February 2009/ Returned for modification 11 May 2009/ Accepted 16 July 2009

Many clinicians are trying unique strategies, including vancomycin and linezolid in combination, for treatment of patients who do not respond to conventional therapy against methicillin (meticillin)-resistant Staphylococcus aureus. In our study, which illustrated in vitro activity only, no synergistic activity was seen when the two agents were combined. Conversely, antagonistic activity occurred in three of five strains when linezolid was added to vancomycin. Our results indicate that vancomycin and linezolid in combination should be avoided.

* Corresponding author. Mailing address: Christiana Care Health System, Medicine Office Room 5236, 501 W. 14th Street, Wilmington, DE 19801. Phone: (302) 428-4672. Fax: (302) 428-2569. E-mail: ssingh{at}christianacare.org

{triangledown} Published ahead of print on 27 July 2009.

Antimicrobial Agents and Chemotherapy, October 2009, p. 4495-4497, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00237-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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