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Antimicrobial Agents and Chemotherapy, October 2009, p. 4498-4500, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00287-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Fluoroquinolone Resistance in Mycobacterium tuberculosis and Mutations in gyrA and gyrB{triangledown}

Andrea Von Groll,1 Anandi Martin,1 Pontus Jureen,2 Sven Hoffner,2 Peter Vandamme,3 Françoise Portaels,1 Juan Carlos Palomino,1 and Pedro Almeida da Silva4*

Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium,1 Laboratory of Tuberculosis, Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna, Sweden,2 Laboratory of Microbiology, Ghent University, Ghent, Belgium,3 Laboratory of Mycobacteriology, Universidade Federal do Rio Grande (FURG), Rio Grande, Brazil4

Received 3 March 2009/ Returned for modification 24 June 2009/ Accepted 5 August 2009

This study evaluated cross-resistance of Mycobacterium tuberculosis strains to ofloxacin, moxifloxacin, and gatifloxacin and investigated the presence of mutations in gyrA and gyrB. Fluoroquinolone susceptibilities were determined for 41 M. tuberculosis strains by the proportion method on 7H11, and MICs were determined by the resazurin microtiter assay. Forty strains shared the same resistance results for the three fluoroquinolones. However, one strain, with an Asn-533 -> Thr mutation in gyrB, was susceptible to ofloxacin but resistant to moxifloxacin and gatifloxacin.

* Corresponding author. Mailing address: Rua General Osorio S/N, Universidade Federal do Rio Grande (FURG), Laboratorio de Mycobacteriologia, Rio Grande 96200190, Brazil. Phone: 55 53 32338895. Fax: 55 53 32338863. E-mail: pedre{at}furg.br

{triangledown} Published ahead of print on 17 August 2009.

Antimicrobial Agents and Chemotherapy, October 2009, p. 4498-4500, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00287-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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