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Antimicrobial Agents and Chemotherapy, October 2009, p. 4501-4503, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00671-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Antiviral Activity of V-073 against Polioviruses {triangledown}

M. Steven Oberste,1 Deborah Moore,1 Barbara Anderson,1 Mark A. Pallansch,1 Daniel C. Pevear,2 and Marc S. Collett3*

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia,1 Protez Pharmaceuticals, Inc., Malvern, Pennsylvania,2 ViroDefense Inc., Rockville, Maryland3

Received 16 May 2009/ Returned for modification 6 July 2009/ Accepted 16 July 2009

V-073, an enterovirus capsid inhibitor, was evaluated for its spectrum of antipoliovirus activity. V-073 inhibited all 45 polioviruses tested in a virus-induced cytopathic effect protection assay, with 50% effective concentration (EC50) values ranging from 0.003 to 0.126 µM. Ninety percent of the polioviruses tested were inhibited at EC50s of ≤0.076 µM (MIC90 = 32 ng/ml). V-073 is a promising antiviral candidate for the posteradication management of poliovirus incidents.

* Corresponding author. Mailing address: ViroDefense Inc., 155 Gibbs Street, Suite 529, Rockville, MD. Phone: (301) 340-1135. Fax: (202) 966-7545. E-mail: mscollett{at}aol.com

{triangledown} Published ahead of print on 27 July 2009.

Antimicrobial Agents and Chemotherapy, October 2009, p. 4501-4503, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00671-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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