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Antimicrobial Agents and Chemotherapy, October 2009, p. 4518-4521, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00461-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

New Variant of CTX-M-Type Extended-Spectrum β-Lactamases, CTX-M-71, with a Gly238Cys Substitution in a Klebsiella pneumoniae Isolate from Bulgaria{triangledown}

Ines Schneider,1 Anne Marie Queenan,2 Rumyana Markovska,3 Boyka Markova,4 Emma Keuleyan,5 and Adolf Bauernfeind1*

MICOER Institute, Munich, Germany,1 Johnson & Johnson Pharmaceutical Research and Development, Raritan, New Jersey,2 Department of Microbiology, Medical University, Sofia, Bulgaria,3 Alexandrovska University Hospital, Sofia, Bulgaria,4 Medical Institute, Ministry of the Interior, Sofia, Bulgaria5

Received 7 April 2009/ Returned for modification 30 May 2009/ Accepted 12 July 2009

A single Klebsiella pneumoniae strain isolated in a Bulgarian hospital was found to produce CTX-M-71, a new CTX-M variant characterized by one amino acid substitution from glycine to cysteine at position 238 in comparison to CTX-M-15. This exchange decreased the hydrolytic activity of the β-lactamase for cefotaxime, ceftazidime, and cefepime.

* Corresponding author. Mailing address: MICOER Institute, Hesseloherstrasse 4, 80802 Munich, Germany. Phone and fax: 49-89-3889 8766. E-mail: bauernfeind{at}aol.com

{triangledown} Published ahead of print on 20 July 2009.

Antimicrobial Agents and Chemotherapy, October 2009, p. 4518-4521, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00461-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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