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Antimicrobial Agents and Chemotherapy, October 2009, p. 4522-4524, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00651-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Longitudinal Analysis of Raltegravir Susceptibility and Integrase Replication Capacity of Human Immunodeficiency Virus Type 1 during Virologic Failure {triangledown}

Signe Fransen,1 Marina Karmochkine,2 Wei Huang,1 Laurence Weiss,2,3 Christos J. Petropoulos,1 and Charlotte Charpentier3,4*

Monogram Biosciences, South San Francisco, California,1 Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service d'Immunologie Clinique, Paris, France,2 Université Paris Descartes, Paris, France,3 Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Laboratoire de Virologie, Paris, France4

Received 13 May 2009/ Returned for modification 8 June 2009/ Accepted 29 July 2009

We characterized the raltegravir (RAL) susceptibility and the integrase (IN)-mediated replication capacity (RC) of RAL-resistant human immunodeficiency virus type 1 from two patients experiencing virologic failure during continuous RAL salvage therapy. The following two distinct outcomes were observed: (i) the selective outgrowth of virus with high-level RAL resistance and high IN-mediated RC leading to significant viral load rebound and (ii) the selection of virus with a slight reduction in RAL susceptibility and low IN-mediated RC resulting in sustained low-level viremia.

* Corresponding author. Mailing address: Hôpital Européen Georges Pompidou, Laboratoire de Microbiologie, 20 Rue Leblanc, 75015 Paris, France. Phone: 33 1 56 09 39 59. Fax: 33 1 56 09 24 47. E-mail: charlotte.charpentier{at}egp.aphp.fr

{triangledown} Published ahead of print on 10 August 2009.

Antimicrobial Agents and Chemotherapy, October 2009, p. 4522-4524, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00651-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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