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Antimicrobial Agents and Chemotherapy, October 2009, p. 4529-4532, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00624-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Panduratin A against Clinical Staphylococcus Strains{triangledown}

Yaya Rukayadi,1,2 Kwanghyung Lee,3 Sunghwa Han,3 Dongeun Yong,4 and Jae-Kwan Hwang1,3*

Department of Biotechnology, Yonsei University, Seoul 120-749, South Korea,1 Biopharmaca Research Center and Research Center for Biotechnology and Bioresources, Bogor Agricultural University, Bogor 16151, Indonesia,2 Department of Biomaterials Science and Engineering, Yonsei University, Seoul 120-749, South Korea,3 Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University, Seoul 120-749, South Korea4

Received 8 May 2009/ Returned for modification 10 July 2009/ Accepted 21 July 2009

In vitro antistaphylococcal activities of panduratin A, a natural chalcone compound isolated from Kaempferia pandurata Roxb, were compared to those of commonly used antimicrobials against clinical staphylococcal isolates. Panduratin A had a MIC at which 90% of bacteria were inhibited of 1 µg/ml for clinical staphylococcal isolates and generally was more potent than commonly used antimicrobials.

* Corresponding author. Mailing address: Department of Biotechnology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-749, Republic of Korea. Phone: 82-2-2123-5881. Fax: 82-2-362-7265. E-mail: jkhwang{at}yonsei.ac.kr

{triangledown} Published ahead of print on 3 August 2009.

Antimicrobial Agents and Chemotherapy, October 2009, p. 4529-4532, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00624-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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