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Antimicrobial Agents and Chemotherapy, October 2009, p. 4537-4539, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00785-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Postantibiotic Effect of Ceftaroline against Gram-Positive Organisms

G. A. Pankuch and P. C. Appelbaum^*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 12 June 2009/ Returned for modification 12 July 2009/ Accepted 8 August 2009

The postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects (SMEs) of ceftaroline, a novel injectable cephalosporin, were determined for 15 gram-positive organisms. The pneumococcal, staphylococcal, and enterococcal PAEs were 0.8 to 1.8 h, 0.7 to 2.2 h, and 0.2 to 1.1 h, respectively. The corresponding PA-SMEs (0.4 times the MIC) were 2.5 to 6.7 h, 2.9 to >0.0 h, and 7.9 to >10.3 h, respectively. The PA-SMEs were longer than the PAEs, suggesting that sub-MIC levels extend the PAE of ceftaroline against gram-positive cocci.

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* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

Published ahead of print on 21 September 2009.

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Antimicrobial Agents and Chemotherapy, October 2009, p. 4537-4539, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00785-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.