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Antimicrobial Agents and Chemotherapy, October 2009, p. 4540-4541, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00565-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Efficacy of Albaconazole against Candida albicans in a Vaginitis Model{triangledown}

Gloria M. González,1* Efrén Robledo,1 Elvira Garza-González,1 Mariana Elizondo,1 and J. Gerardo González2

Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México,1 Hospital Universitario, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México2

Received 27 April 2009/ Returned for modification 29 May 2009/ Accepted 17 July 2009

The efficacy of albaconazole (ABC) was evaluated using a murine model of vaginal Candida albicans infection. Both ABC and fluconazole (FLC) were effective in reducing the fungal load from vaginas of infected mice; however, ABC demonstrated encouraging activities against an FLC-resistant strain, with trends toward superiority over FLC in some treatment groups.

* Corresponding author. Mailing address: Facultad de Medicina, Universidad Autónoma de Nuevo León, Departamento de Microbiología, Madero y Dr. E. A. Pequeño s/n, Colonia Mitras Centro, Monterrey, Nuevo León, México 64460. Phone: (5281) 83294157. Fax: (5281) 83485477. E-mail: gmglez{at}yahoo.com.mx

{triangledown} Published ahead of print on 27 July 2009.

Antimicrobial Agents and Chemotherapy, October 2009, p. 4540-4541, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00565-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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