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Antimicrobial Agents and Chemotherapy, October 2009, p. 4549-4555, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00180-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Evaluating Aztreonam and Ceftazidime Pharmacodynamics with Escherichia coli in Combination with Daptomycin, Linezolid, or Vancomycin in an In Vitro Pharmacodynamic Model {triangledown}

Kerry L. LaPlante1,2* and George Sakoulas3,4,5

Department of Pharmacy Practice, University of Rhode Island, Kingston, Rhode Island,1 Veterans Affairs Medical Center, Providence, Rhode Island,2 Division of Infectious Diseases, New York Medical, College, Valhalla, New York,3 Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California,4 Sharp Memorial Hospital, San Diego, California5

Received 9 February 2009/ Returned for modification 5 April 2009/ Accepted 10 July 2009

In an in vitro pharmacodynamic model, linezolid attenuated the activity of aztreonam and ceftazidime against Escherichia coli. Conversely, synergy was detected at 24 and 48 h when daptomycin or vancomycin was added to aztreonam and ceftazidime. We conclude that significant yet underappreciated interactions may occur between gram-positive-spectrum and gram-negative-spectrum antibacterials.

* Corresponding author. Mailing address: University of Rhode Island, Department of Pharmacy Practice, Veterans Affairs Medical Center (151), Research Building #35, 830 Chalkstone Avenue, Providence, RI 02908. Phone: (401) 273-7100, ext. 2339. Fax: (401) 457-3305. E-mail: KerryTedesco{at}uri.edu

{triangledown} Published ahead of print on 20 July 2009.

Antimicrobial Agents and Chemotherapy, October 2009, p. 4549-4555, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.00180-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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