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Antimicrobial Agents and Chemotherapy, October 2009, p. 4559-4562, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.01404-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antifungal Activity of Micafungin in Serum {triangledown}

Jun Ishikawa,1 Tetsuo Maeda,1 Itaru Matsumura,1* Masato Yasumi,1 Hidetoshi Ujiie,1 Hiroaki Masaie,1 Tsuyoshi Nakazawa,1 Nobuo Mochizuki,2 Satoshi Kishino,2 and Yuzuru Kanakura1

Department of Hematology and Oncology, Osaka University School of Medicine, Osaka, Japan,1 Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Tokyo, Japan2

Received 20 October 2008/ Returned for modification 18 January 2009/ Accepted 5 August 2009

We have evaluated the antifungal activity of micafungin in serum by using the disk diffusion method with serum-free and serum-added micafungin standard curves. Serum samples from micafungin-treated patients have been shown to exhibit adequate antifungal activity, which was in proportion to both the applied dose and the actual concentration of micafungin measured by high-performance liquid chromatography. The antifungal activity of micafungin in serum was also confirmed with the broth microdilution method.

* Corresponding author. Mailing address: Department of Hematology and Oncology, Osaka University School of Medicine, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan. Phone: 81-6-6879-3871. Fax: 81-6-6879-3879. E-mail: matumura{at}bldon.med.osaka-u.ac.jp

{triangledown} Published ahead of print on 17 August 2009.

Antimicrobial Agents and Chemotherapy, October 2009, p. 4559-4562, Vol. 53, No. 10
0066-4804/09/$08.00+0     doi:10.1128/AAC.01404-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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