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Antimicrobial Agents and Chemotherapy, November 2009, p. 4924-4926, Vol. 53, No. 11
0066-4804/09/$08.00+0     doi:10.1128/AAC.00786-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Colistin (Polymyxin E) against 3,480 Isolates of Gram-Negative Bacilli Obtained from Patients in Canadian Hospitals in the CANWARD Study, 2007-2008{triangledown}

A. Walkty,1* M. DeCorby,2 K. Nichol,1 J. A. Karlowsky,1,2 D. J. Hoban,1,2 and G. G. Zhanel1,2

Departments of Medicine and Clinical Microbiology, Health Sciences Centre,1 Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada2

Received 12 June 2009/ Returned for modification 20 July 2009/ Accepted 12 August 2009

The in vitro activity of colistin was evaluated versus 3,480 isolates of gram-negative bacilli using CLSI broth microdilution methods. The MIC90 of colistin was ≤2 µg/ml against a variety of clinically important gram-negative bacilli, including Escherichia coli, Klebsiella spp., Enterobacter spp., Acinetobacter baumannii, and Pseudomonas aeruginosa. All multidrug-resistant (n = 76) P. aeruginosa isolates were susceptible to colistin (MIC, ≤2 µg/ml). These data support a role for colistin in the treatment of infections caused by multidrug-resistant P. aeruginosa.

* Corresponding author. Mailing address: Health Sciences Centre, Department of Clinical Microbiology, MS673-820 Sherbrook St., Winnipeg, Manitoba, Canada R3A 1R9. Phone: (204) 453-3867. Fax: (204) 787-4699. E-mail: awalkty{at}mts.net

{triangledown} Published ahead of print on 24 August 2009.

Antimicrobial Agents and Chemotherapy, November 2009, p. 4924-4926, Vol. 53, No. 11
0066-4804/09/$08.00+0     doi:10.1128/AAC.00786-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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