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Antimicrobial Agents and Chemotherapy, November 2009, p. 4927-4929, Vol. 53, No. 11
0066-4804/09/$08.00+0     doi:10.1128/AAC.00689-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

ATP Synthase Inhibition of Mycobacterium avium Is Not Bactericidal{triangledown}

Nacer Lounis, Tom Gevers, Joke Van Den Berg, Luc Vranckx, and Koen Andries*

Department of Antimicrobial Research, Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium

Received 20 May 2009/ Returned for modification 11 June 2009/ Accepted 31 August 2009

The efficacy of ATP synthase inhibitor TMC207 was assessed in early and late Mycobacterium avium infections in mice. In contrast to what was earlier observed for M. tuberculosis, a bacteriostatic effect was obtained. In vitro, the minimal bactericidal concentration (MBC)/MIC ratio was very high. The MBC was more relevant for assessment of pharmacokinetic/pharmacodynamic relationships than the MIC.

* Corresponding author. Mailing address: Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium. Phone: 32 14 60 20 33. Fax: 32 14 60 51 71. E-mail: kandries{at}its.jnj.com

{triangledown} Published ahead of print on 8 September 2009.

Antimicrobial Agents and Chemotherapy, November 2009, p. 4927-4929, Vol. 53, No. 11
0066-4804/09/$08.00+0     doi:10.1128/AAC.00689-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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