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Antimicrobial Agents and Chemotherapy, November 2009, p. 4934-4937, Vol. 53, No. 11
0066-4804/09/$08.00+0     doi:10.1128/AAC.00796-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Pulmonary Epithelial Lining Fluid Concentrations after Use of Systemic Amphotericin B Lipid Formulations{triangledown}

Stefan Weiler,1 Gerda Falkensammer,2,{dagger} Angelika Hammerer-Lercher,2 Markus Anliker,2 Helene Vogelsinger,1 Michael Joannidis,3 Stefan Dunzendorfer,3 Markus Stein,3,{ddagger} and Romuald Bellmann1,3*

Clinical Pharmacokinetics Unit, Inflammation Research Laboratory, Department of Internal Medicine I, Innsbruck Medical University,1 Central Institute for Medical and Chemical Laboratory Diagnostics, Innsbruck General Hospital,2 Medical Intensive Care Unit, Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria3

Received 15 June 2009/ Returned for modification 11 July 2009/ Accepted 13 August 2009

Amphotericin B (AMB) concentrations were determined in pulmonary epithelial lining fluid (ELF) of 44 critically ill patients, who were receiving treatment with liposomal AMB (LAMB) (n = 11), AMB colloidal dispersion (ABCD) (n = 28), or AMB lipid complex (ABLC) (n = 5). Mean AMB levels (± standard errors of the means) in ELF amounted to 1.60 ± 0.58, 0.38 ± 0.07, and 1.29 ± 0.71 µg/ml in LAMB-, ABCD-, and ABLC-treated patients, respectively (differences are not significant).

* Corresponding author. Mailing address: Department of Internal Medicine I, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria. Phone: 43 512 504 81389. Fax: 43 512 504 24199. E-mail: romuald.bellmann{at}i-med.ac.at

{triangledown} Published ahead of print on 24 August 2009.

{dagger} Present address: Krankenhaus der Elisabethinen, Linz, Austria.

{ddagger} Present address: Krankenhaus Natters, Natters, Austria.

Antimicrobial Agents and Chemotherapy, November 2009, p. 4934-4937, Vol. 53, No. 11
0066-4804/09/$08.00+0     doi:10.1128/AAC.00796-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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